Cinchonidiae Sulphas.

In the earlier manufacture of quinine this alkaloid with others was thrown away in the mother liquor. Afterwards this liquor was evaporated to an extract and held in stock until large quantities had accumulated, when it was found profitable to work it over and remove the alkaloids. Thus when the agent under consideration was introduced there was a large stock, and it was sold at a very low price.

Dose.—The dose will range from one to five grains, the antiperiodic quantity being fifteen to twenty grains.

Therapeutic Action.—In almost every respect this salt is similar to sulphate of quinine. It hus the same tonic and autiperiodic properties, but is probably not quite so active. It haa been claimed that it is not so apt to produce head symptoms, and that it is more kindly received by the stomach. It is not so bitter, and some persons take it more easily. As to its certainty, there is a difference of opinion. Whilst some claim that it is less certain, others think there is a greater degree of certainty.

It is to be recommended in place of quinine only when, the difference in price makes it an object, and then it may be used for the same purposes, and in the same doses.

The American Eclectic Materia Medica and Therapeutics, 1898, was written by John M. Scudder, M.D.